Super-contagious COVID variant XE has a key deficiency that could be our saving grace. XE may be more contagious than BA.2 — but its spike protein isn't different. Here's why that's a good thing
At the beginning of this year, the extremely contagious BA.1 variant (also known as the omicron variant) set an astonishing record: scientists believed it was likely the most contagious virus ever, surpassing even measles.
That is, until BA.2 — or "stealth" omicron, as it has been called — came along. Studies suggest that BA.2 is between 30 and 50 percent even more contagious than its predecessor, which was already more contagious than measles.
But while contagiousness is certainly an alarming trait for a viral mutation, scientists warn that the worst possible mutation would be the emergence of a new variant that was both contagious and more inclined to cause severe disease. Luckily, BA.1 and BA.2 don't fit that bill. Indeed, while BA.2, according to the U.S. Centers for Disease Control and Prevention (CDC), caused 86 percent of new COVID-19 cases in the U.S. last week, hospitalizations remain quite low.
But just as public health experts seemed to get a grip on the situation with BA.1 and BA.2, a newer, odder variant has emerged. It's called XE, it's a hybrid between BA.1 and BA.2, and it's extremely transmissible. Could this pose a renewed threat to global public health?
Salon spoke to experts about what we know so far about this new variant and the threat that it poses. Crucially, XE seems to have one key deficiency that will prevent it from attaining that secret sauce that makes variants more dangerous.
XE is on the rise in the United Kingdom. According to recent data from the U.K. Health Security Agency, 1,125 cases of XE have been identified in the country as of April. That number is about 50 percent more than what public health officials identified a week prior on March 25. The variant was first identified on January 19, 2022 in the United Kingdom. XE has since been detected in Thailand, India, Israel and most recently, Japan; the U.S. has not yet reported any XE cases yet.
Sriram Subramaniam, a biochemist at the University of British Columbia, told Salon that despite the rise, XE is still relatively low in prevalence in the United Kingdom.
"Given the current high level of transmission worldwide, it is likely that further variants, including recombinants, will continue to emerge. It doesn't look like it's taken off in a big way yet," Subramaniam said. "There are some cases in various parts of the world — and it's not just XE, there's XD and XF," he noted, referring to initialisms for subsequently mutated sub-variants.
XE may be more transmissible than BA.2
As Subramaniam mentioned, XE is one of three recombinant variants being monitored by the U.K. Health Security Agency (UKHSA). A recombinant variant occurs when a new SARS-CoV-2 variant develops by picking up traits from previous variants — recombining into something completely novel, a hybrid of sorts, with traits from multiple forebears. As previously mentioned, XE is essentially a hybrid between BA.1 and BA.2; the other two recombinant variants — XD and XF — are recombinants of delta and omicron BA.1.
According to the UKHSA, 38 cases of XF have been identified in the U.K., but none have been seen since mid-February. XD hasn't been identified in the U.K. at all, and only 49 cases have been reported globally, most of which are in France. This is why, among the three, XE is hogging the headlines.
Yet the U.K. hasn't yet collected enough data to say definitively how contagious XE is. Specifically, UKHSA says "there is currently insufficient evidence to draw conclusions about growth advantage or other properties of this variant."