Yeah, by relative isolation I mean that if you're in a Western city and you want to go to another city in any kind of reasonable timeframe, you've almost certainly got to fly, whereas if you're in Montreal, huge chunks of the populated North America are car trippable.
If you play in Winnipeg, you can drive to places like Thunder Bay, Fargo, Regina, and Saskatoon in a day. If you play in Montreal, you can easily drive to Boston, Toronto, Ottawa, New York City, or Quebec City in a day.
I'm not saying that this is super important to any particular football player, but when my family's considered moving back to a Canadian city, the isolation of the West is something we think about.