Yes, but also no. It's not so cut and dry. I doubt Griffiths and Jake will be on the field much at all together, to be honest ... it just seems like an inefficient use of personnel.
I think we're more likely to see Jeffcoat/Jefferson line up inside, some packages involving Antigha and Jefferson where they mix and match to create a 3 man rush and drop one of them back into coverage, all that kind of stuff before we see our two DTs that are lesser talents than so many other options taking snaps at the same time. Will it happen? Almost definitely. Often? I doubt it and I also hope not.